Endoplasmic reticulum stress and atf3
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WebApr 13, 2024 · HIGHLIGHTS. who: Marc-Antoine Campeau from the DepartmentMcGill University, Montreal, QC, Canada have published the Article: Empagliflozin mitigates … Activating transcription factor 3 (ATF3) is a member of the ATF/cAMP response element-binding (CREB) family, which binds to the cyclic AMP response element (CRE) in numerous promoters with the consensus sequence TGACGTCA (1, 2). Besides, other sequences of ATF3 binding site on the target … See more ATF3 is involved in glucose metabolism in a variety of organs and tissues, including the pancreas, liver, adipose tissue, hypothalamus, and … See more ATF3 is upregulated in the WAT of obese mice (36). ATF3 can downregulate the expression of C/EBPα (37) or PPARγ (38), resulting in suppression of adipocyte differentiation. Kim et … See more Elevated expression levels of ATF3 have been noted in normal human prostate tissue and the androgen-dependent prostate cancer cell line LNCap, but weak expression levels of … See more ATF3 induction has been observed in response to a broad range of Toll-like receptors (TLRs), including TLR4, 2/6, 3, 5, 7, and 9 (3). Consequently, ATF3−/− primary … See more
Endoplasmic reticulum stress and atf3
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WebMay 12, 2016 · Endoplasmic reticulum stress and unfolded protein response in multiple myeloma cell BTZ is a boronic acid dipeptide that inhibits activations of β5 and β1 subunits of the 20S proteasome core in the 26S proteasome complex, and is characterized as a reversible inhibitor of the above activities [ 6 ]. WebAug 1, 2014 · In this report, we demonstrate that the stress response gene ATF3 is required for endoplasmic reticulum stress-mediated DR5 induction upon zerumbone (ZER) and …
WebPhenylbutyric acid (PBA) is a commonly used inhibitor of endoplasmic reticulum stress, as well as a histone deacetylase (HDAC) inhibitor, that increases hypothalamic expression of orexigenic neuropeptide Y (Npy). Elucidation of the dose-response relationship and mechanism of action of PBA may position this compound as a potential therapeutic ...
WebJul 18, 2024 · The most highly significant up-regulated genes (FDR < 10 −5) were related to apoptosis followed closely by endoplasmic reticulum stress and unfolded protein response (FDR < 10 −4). Markers of the unfolded protein response (ATF3, ATF4, and DDIT3—also referred to as CHOP) were retested by qRT-PCR and their mRNA levels … WebApr 12, 2024 · This systematic review aims to summarize the involvement of endoplasmic reticulum stress (ERS) and subsequent unfolded protein response (UPR) as the underlying molecular mechanisms for the anticancer properties of tocotrienol.
WebMar 30, 2024 · 1. Introduction. Stress is a systemic and non-specific adaptive response of the body to the stimuli from various stressors in the internal and external environment …
WebATF3 is also a stress-inducible gene. Overwhelming evidence from many laboratories indicates that ATF3 is induced by a variety of stress signals. lagu rohani segala perkara dapat ku tanggungWebMar 30, 2024 · Stress has become a universal biological phenomenon in the body, which leads to pathophysiological changes. However, the molecular network interactions between endoplasmic reticulum (ER) stress and ferroptosis … lagu rohani sehangat matahariWebMay 20, 2014 · We further show that small molecule inhibition of system x c− function leads to endoplasmic reticulum (ER) stress, as indicated by the transcriptional upregulation of genes linked to the ER stress response. lagu rohani semangat pagiWebApr 12, 2024 · HIGHLIGHTS who: Shuwei Hu and colleagues from the (UNIVERSITY) have published the Article: Activating transcription factor 3, glucolipid metabolism, and metabolic diseases, in the Journal: (JOURNAL) SUMMARY Glucolipid metabolism with … Activating transcription factor 3, glucolipid metabolism, and metabolic diseases Read Research » jeff britta ao3WebClick the image above or here to open this pathway in the Pathway Browser ATF4 is a transcription factor and activates expression of IL-8, MCP1, IGFBP-1, CHOP, HERP1 and ATF3. Literature References Participants Events Expression of ATF3 (Homo sapiens) Expression of ASNS (Asparagine Synthetase) (Homo sapiens) Expression of CCL2 … lagu rohani segala puji syukurWebOct 23, 2024 · Here, we showed that DDX3 positively regulates ATF4 mRNA expression during ER stress induced by Sor treatment of cancer cells. We found that DDX3 drives stress-induced ATF4 mRNA … jeff brohm going to louisvilleWebApr 12, 2024 · Background: Tocotrienol, a type of vitamin E, is well known for its anti-cancer and other biological activities. This systematic review aims to summarize the involvement … jeff buckley just like a woman