Irisin ferroptosis

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August undefined, 2024

WebIrisin, a proteolytic cleavage product of ﬁbronectin type III domain- containingprotein5(FNDC5),isarecentlycharacterizedmulti-func- tional myokine with … WebSep 25, 2024 · We observed that irisin can augment ferroptosis-associated increases in free iron concentrations, lipid peroxide levels, and GSH depletion, while increasing the pancreatic cancer cell death rate.

Involvement of GPX4 in irisin

WebFeb 15, 2024 · Irisin is highly preserved in all mammalian species analyzed. Mouse irisin and human irisin are 100% identical, compared to the identity of 85% for insulin, 90% for glucagon and 83% for leptin. This implicates a highly preserved function which is probably mediated by a membrane receptor expressed on the cell surface [1]. 1.3. WebOct 28, 2024 · Ferroptosis was clearly defined in 2012 as a newly discovered iron-dependent, peroxide-driven, nonapoptotic form of regulated cell death. Ferroptosis is considered the cause of reperfusion injury. This discovery provides new avenues for the recognition and treatment of diseases. highline investment advisors

Post-treatment With Irisin Attenuates Acute Kidney Injury …

WebJul 1, 2024 · Ferroptosis is involved in the pathological process of SAE. • Irisin suppressed neurons ferroptosis via Nrf2 pathway. • Irisin ameliorates SAE-induced inflammatory microenvironment through inhibiting hippocampus ferroptosis. • Irisin could attenuate cognitive dysfunction of SAE via ferroptosis resistance. Abstract WebThis study was aimed at verifying that irisin postconditioning can inhibit ferroptosis and minimize lung ischemia/reperfusion (I/R) damage via activating the Nrf2/HO-1 signal axis. small rash around mouth

Irisin - an overview ScienceDirect Topics

Irisin Is a Positive Regulator for Ferroptosis in Pancreatic Cancer

WebJan 15, 2024 · Irisin serves as a novel approach to eliciting cardioprotection, which is associated with the improvement of mitochondrial function and significantly attenuated hypoxia/reoxygenation (H/R), as indicated by the reduction of lactate dehydrogenase (LDH) leakage and apoptotic cardiomyocytes. 99 PDF View 1 excerpt, references background WebSep 1, 2024 · The effect of irisin on ferroptosis was confirmed in LPS-treated hepatocytes and CLP-induced septic mice. Inhibition of glutathione peroxidase 4 (GPX4), a central … highline investments gp limitedWebJun 13, 2024 · Ferroptosis is involved in the ischemia–reperfusion injury (IRI) during LT with a severe steatotic donor liver and HM-exos treatment attenuated graft IRI, which might be a promising strategy to treat IRI in Steatotic grafts. 12 PDF View 1 excerpt, cites background highline investments

"WebOct 28, 2024 · Ferroptosis was clearly defined in 2012 as a newly discovered iron-dependent, peroxide-driven, nonapoptotic form of regulated cell death. Ferroptosis is considered the cause of reperfusion injury. This discovery provides new avenues for the recognition and treatment of diseases. " - Irisin ferroptosis

Irisin ferroptosis

Postconditioning with Irisin Attenuates Lung Ischemia/Reperfusio…

WebMay 25, 2024 · Ferroptosis is an iron-dependent, nonapoptotic cell death method characterized by abnormal accumulation of lipid hydroperoxide and related lipophilic reactive oxygen species (ROS) in the cell membrane [ 7, … WebIrisin is a novel exercise-induced myokine involved in the regulation of adipose browning and thermogenesis. This study is designed to verify the existence of ferroptosis in the …

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WebJul 1, 2024 · Ferroptosis contributes to the onset or progression of various metabolic diseases. Ferritinophagy is a selective type of autophagy, which induces ferroptosis by degrading ferritin and inducing iron overload. Ferritinophagy inhibition may ameliorate ferroptosis and ease the management of metabolic diseases. Ferroptosis, which triggers … WebDec 8, 2024 · The upregulation of GPX4 leads to an irisin-mediated decrease in acute kidney injury (AKI) induced by ischemia-reperfusion (I/R). However, the protective effect of irisin was disrupted by GPX4 inhibitor RSL3 (Zhang J. et al., 2024). Ferroptosis is closely related to hypertensive brain injury.

WebJul 1, 2024 · Irisin is a novel exercise-induced myokine involved in the regulation of adipose browning and thermogenesis. This study is designed to verify the existence of ferroptosis in the pathogenesis of SAE and demonstrate that irisin attenuated cognitive dysfunction in SAE mice via inhibition of hippocampus ferroptosis. WebSep 9, 2024 · Irisin, a proteolytic cleavage product of fibronectin type III domain-containing protein 5 (FNDC5), is a recently characterized multi-functional myokine with hormonal …

WebSep 1, 2024 · Ferroptosis, an iron-dependent programmed cell death, has been proposed to be related to the pathogenesis of sepsis. Irisin, a myokine released during exercise, improves mitochondrial function... WebDec 1, 2024 · Zhang et al. found that irisin reduced ROS level, iron content, MDA level, increased GSH level in mice, and adjusted the expression of GPX4 and ACSL4 to reduce ferroptosis. In the process of the study, irisin also inhibited ROS accumulation and iron content increase in HK-2 cells. And improve the function of mitochondria [51].

WebMay 7, 2024 · Ferroptosis is a form of cell death that is regulated by multiple genes and involves multiple metabolic processes, such as iron homeostasis, amino acid metabolism and lipid peroxidation. The mechanism is very complex as is shown in Figure 1, and it will be better explained in the following aspects. FIGURE 1 Figure 1. Main mechanisms of …

WebSep 1, 2024 · Irisin is a novel exercise-induced myokine involved in the regulation of adipose browning and thermogenesis. This study is designed to verify the existence of ferroptosis in the pathogenesis of SAE and demonstrate that irisin attenuated cognitive dysfunction in SAE mice via inhibition of hippocampus ferroptosis. small rash all over bodyWebDec 8, 2024 · The upregulation of GPX4 leads to an irisin-mediated decrease in acute kidney injury (AKI) induced by ischemia-reperfusion (I/R). However, the protective effect of irisin … small ranches for sale in texas hill countryWebRecently, irisin treatment prevented I/R lung damage by suppressing ferroptosis through the Nrf2/HO-1 axis , which was similar to the effect of Fer-1. These findings indicate the … small raptors birdsWebMay 12, 2024 · Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways). highline investment partnersWebAug 5, 2024 · Irisin Is a Positive Regulator for Ferroptosis in Pancreatic Cancer Regulated cell death by way of ferroptosis involves iron-dependent accumulation of cellular reactive … highline investments llcWebSep 17, 2024 · Intriguingly, Yang et al. found that irisin was a positive regulator of ferroptosis. Irisin decreased GXP4 expression and upregulated ROS production to … small rasbora speciesWebMar 17, 2024 · Irisin Mitigates Ferroptosis and Mitochondria Dysfunction in LPS-Induced HK2 Cells. Based on the aforementioned findings in vivo, we next evaluated the function … small rash dots shaped in circle